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Utilizing the GCRLE grant, Munakata and Namekawa will search extra intently at how oocytes are genomically primed and stored for afterwards use. They will examine the role of the chromatin remodeler in oocyte survival and fertility.
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Namekawa believes that in human oocytes, changes in these designs could disrupt the sensitive choreography of genes getting turned on and off at the correct occasions — leaving them unprepared for fertilization or growth into nutritious embryos. Improvements in chromatin framework as an oocyte ages may also affect the way in which that chromosomes segregate all through cell division.
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